In MCF-7 xenografts, their antiproliferative actions were accompanied by a significantly reduced apoptotic index. In vitro, R 4891 and RU 23908 were as effective as R 227 in inhibiting proliferation of MCF-7 cells in cell cycle analysis. ![]() Antiandrogens R 4891 and RU 23908 significantly inhibited the development of MCF-7 breast cancer xenografts in nude mice. ICR female mice were inoculated with a human breast cancer cell line (MCF-7 cells). We report the effects of antiandrogens on breast tumor growth in a unique xenograft model. Kamiya Satoshi.Antiproliferative action of antiandrogens in human breast cancer. ![]() Satoshi Kamiya was an origami artist who died in 2006.
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